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CTLA-4 Modulates the Differentiation of Inducible Foxp3(+) Treg Cells but IL-10 Mediates Their Function in Experimental Autoimmune Encephalomyelitis

In vitro induced Foxp3(+) T regulatory (iTreg) cells form a novel and promising target for therapeutic tolerance induction. However, the potential of these cells as a target for the treatment of various immune diseases, as well as the factors involved in their development and function, remain debate...

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Detalles Bibliográficos
Autores principales: Verhagen, Johan, Gabryšová, Leona, Shepard, Ella R., Wraith, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169598/
https://www.ncbi.nlm.nih.gov/pubmed/25238105
http://dx.doi.org/10.1371/journal.pone.0108023