Structural basis of Ets1 activation by Runx1

Runx1 is required for definitive hematopoiesis and is well-known for its frequent chromosomal translocations and point mutations in leukemia. Runx1 regulates a variety of genes via Ets1 activation on an Ets1•Runx1 composite DNA sequence. The structural basis of such regulation remains unresolved. To...

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Detalles Bibliográficos
Autores principales: Shrivastava, Tripti, Mino, Koshiki, Babayeva, Nigar D., I.Baranovskaya, Oxana, Rizzino, Angie, Tahirov, Tahir H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169772/
https://www.ncbi.nlm.nih.gov/pubmed/24646888
http://dx.doi.org/10.1038/leu.2014.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169772/
https://www.ncbi.nlm.nih.gov/pubmed/24646888
http://dx.doi.org/10.1038/leu.2014.111

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