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Structural basis of Ets1 activation by Runx1

Runx1 is required for definitive hematopoiesis and is well-known for its frequent chromosomal translocations and point mutations in leukemia. Runx1 regulates a variety of genes via Ets1 activation on an Ets1•Runx1 composite DNA sequence. The structural basis of such regulation remains unresolved. To...

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Detalles Bibliográficos
Autores principales:	Shrivastava, Tripti, Mino, Koshiki, Babayeva, Nigar D., I.Baranovskaya, Oxana, Rizzino, Angie, Tahirov, Tahir H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169772/ https://www.ncbi.nlm.nih.gov/pubmed/24646888 http://dx.doi.org/10.1038/leu.2014.111

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