Structural analyses of Ca(2+)/CaM interaction with Na(V) channel C-termini reveal mechanisms of calcium-dependent regulation

Ca(2+) regulates voltage-gated Na(+) (Na(V)) channels and perturbed Ca(2+) regulation of Na(V) function is associated with epilepsy syndromes, autism, and cardiac arrhythmias. Understanding the disease mechanisms, however, has been hindered by a lack of structural information and competing models fo...

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Detalles Bibliográficos
Autores principales: Wang, Chaojian, Chung, Ben C., Yan, Haidun, Wang, Hong-Gang, Lee, Seok-Yong, Pitt, Geoffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170523/
https://www.ncbi.nlm.nih.gov/pubmed/25232683
http://dx.doi.org/10.1038/ncomms5896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170523/
https://www.ncbi.nlm.nih.gov/pubmed/25232683
http://dx.doi.org/10.1038/ncomms5896

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