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Structural analyses of Ca(2+)/CaM interaction with Na(V) channel C-termini reveal mechanisms of calcium-dependent regulation
Ca(2+) regulates voltage-gated Na(+) (Na(V)) channels and perturbed Ca(2+) regulation of Na(V) function is associated with epilepsy syndromes, autism, and cardiac arrhythmias. Understanding the disease mechanisms, however, has been hindered by a lack of structural information and competing models fo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170523/ https://www.ncbi.nlm.nih.gov/pubmed/25232683 http://dx.doi.org/10.1038/ncomms5896 |