Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts

The molecular co-chaperone CDC37 is over-expressed in hepatocellular carcinoma (HCC) cells, where it functions with HSP90 to regulate the activity of protein kinases in multiple oncogenic signaling pathways that contribute towards hepatocarcinogenesis. Disruption of these signaling pathways via inhi...

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Detalles Bibliográficos
Autores principales: Wei, Wei, Wu, Song, Wang, Xiaolin, Sun, Chris Kin-Wai, Yang, Xiaoyang, Yan, Xinrui, Chua, Mei-Sze, So, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170594/
https://www.ncbi.nlm.nih.gov/pubmed/25051375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170594/
https://www.ncbi.nlm.nih.gov/pubmed/25051375

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