Heparin and Liver Heparan Sulfate Can Rescue Hepatoma Cells from Topotecan Action

Topotecan (TpT) is a major inhibitory compound of topoisomerase (topo) I that plays important roles in gene transcription and cell division. We have previously reported that heparin and heparan sulfate (HS) might be transported to the cell nucleus and they can interact with topoisomerase I. We hypot...

Descripción completa

Detalles Bibliográficos
Autores principales: Dudás, József, Bocsi, József, Fullár, Alexandra, Baghy, Kornélia, Füle, Tibor, Kudaibergenova, Saule, Kovalszky, Ilona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170749/
https://www.ncbi.nlm.nih.gov/pubmed/25309924
http://dx.doi.org/10.1155/2014/765794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170749/
https://www.ncbi.nlm.nih.gov/pubmed/25309924
http://dx.doi.org/10.1155/2014/765794

Ejemplares similares