Cargando…

Heparin and Liver Heparan Sulfate Can Rescue Hepatoma Cells from Topotecan Action

Topotecan (TpT) is a major inhibitory compound of topoisomerase (topo) I that plays important roles in gene transcription and cell division. We have previously reported that heparin and heparan sulfate (HS) might be transported to the cell nucleus and they can interact with topoisomerase I. We hypot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dudás, József, Bocsi, József, Fullár, Alexandra, Baghy, Kornélia, Füle, Tibor, Kudaibergenova, Saule, Kovalszky, Ilona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170749/ https://www.ncbi.nlm.nih.gov/pubmed/25309924 http://dx.doi.org/10.1155/2014/765794

Ejemplares similares

Lack of Matrilin-2 Favors Liver Tumor Development via Erk1/2 and GSK-3β Pathways In Vivo
por: Fullár, Alexandra, et al.
Publicado: (2014)

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression
por: Fullár, Alexandra, et al.
Publicado: (2015)

Dynamic Interplay in Tumor Ecosystems: Communication between Hepatoma Cells and Fibroblasts
por: Petővári, Gábor, et al.
Publicado: (2023)

Syndecan-1 Enhances Proliferation, Migration and Metastasis of HT-1080 Cells in Cooperation with Syndecan-2
por: Péterfia, Bálint, et al.
Publicado: (2012)

Tumor-produced, active Interleukin-1 β regulates gene expression in carcinoma-associated fibroblasts
por: Dudás, József, et al.
Publicado: (2011)

Inhibitory Effect of (2R)-1-(1-Benzofuran-2-yl)-N-propylpentan-2-amine on Lung Adenocarcinoma
por: Mervai, Zsolt, et al.
Publicado: (2019)

Aberrant Expression of Syndecan-1 in Cervical Cancers
por: Karászi, Katalin, et al.
Publicado: (2020)

Tumor cell and carcinoma-associated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma
por: Fullár, Alexandra, et al.
Publicado: (2012)

Curcumin targets fibroblast–tumor cell interactions in oral squamous cell carcinoma
por: Dudás, József, et al.
Publicado: (2013)

Introduction to the Molecules Special Edition Entitled ‘Heparan Sulfate and Heparin: Challenges and Controversies’: Some Outstanding Questions in Heparan Sulfate and Heparin Research
por: Yates, Edwin A, et al.
Publicado: (2019)

Diverse Roles of Heparan Sulfate and Heparin in Wound Repair
por: Olczyk, Pawel, et al.
Publicado: (2015)

Polymers Inspired by Heparin and Heparan Sulfate for Viral Targeting
por: Hoffmann, Miriam, et al.
Publicado: (2022)

Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse
por: Mervai, Zsolt, et al.
Publicado: (2018)

Two ways of epigenetic silencing of TFPI2 in cervical cancer
por: Fullár, Alexandra, et al.
Publicado: (2020)

Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
por: Karlsson, Richard, et al.
Publicado: (2021)

The Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives
por: Veraldi, Noemi, et al.
Publicado: (2020)

Structure and properties of an under-sulfated heparan sulfate proteoglycan synthesized by a rat hepatoma cell line
Publicado: (1984)

Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor
Publicado: (1990)

By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans
por: Taylor, Sarah L., et al.
Publicado: (2019)

The Solution Structure of Heparan Sulfate Differs from That of Heparin: IMPLICATIONS FOR FUNCTION
por: Khan, Sanaullah, et al.
Publicado: (2013)

Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars
por: Uniewicz, Katarzyna A., et al.
Publicado: (2014)

Heparan sulfates and heparan sulfate binding proteins in sepsis
por: Liao, Yi-En, et al.
Publicado: (2023)

Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions
por: Weiss, Ryan J., et al.
Publicado: (2015)

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors
por: Kim, Ha Na, et al.
Publicado: (2017)

The neutralization of heparan sulfate by heparin-binding copolymer as a potential therapeutic target
por: Kalaska, Bartlomiej, et al.
Publicado: (2019)

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression
por: Nagarajan, Arvindhan, et al.
Publicado: (2018)

Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands
por: Perkins, Stephen J., et al.
Publicado: (2014)

Heparin/Heparan Sulfate Proteoglycans Glycomic Interactome in Angiogenesis: Biological Implications and Therapeutical Use
por: Chiodelli, Paola, et al.
Publicado: (2015)

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding
por: Manikowski, Dominique, et al.
Publicado: (2019)

Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4
por: Sin, Yun Jin Ashley, et al.
Publicado: (2022)

Protective Role of Decorin in Primary Hepatocellular Carcinoma
por: Reszegi, Andrea, et al.
Publicado: (2020)

Syndecan-1 in Liver Diseases
por: Regős, Eszter, et al.
Publicado: (2019)

Can We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard?
por: Farrugia, Brooke L., et al.
Publicado: (2015)

Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9)
por: Honda, Tomoko, et al.
Publicado: (2022)

Combinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development
por: Kinnunen, Tarja K.
Publicado: (2014)

On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different
por: Mosier, Philip D., et al.
Publicado: (2012)

Heparan sulfate gets specific
por: Dove, Alan W.
Publicado: (2001)

Heparan sulfate proteoglycans and cancer
por: Blackhall, F H, et al.
Publicado: (2001)

Heparan Sulfate Proteoglycans in Infection
por: Bartlett, Allison H., et al.
Publicado: (2011)

Heparan Sulfate Proteoglycans in Tauopathy
por: Zhu, Yanan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7f93cef2pjn9msfr066s2tsi3c