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Targeted genomic rearrangements using CRISPR/Cas technology
Genomic rearrangements are frequently observed in cancer cells but have been difficult to generate in a highly specific manner for functional analysis. Here we report the application of CRISPR/Cas technology to successfully generate several types of chromosomal rearrangements implicated as driver ev...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170920/ https://www.ncbi.nlm.nih.gov/pubmed/24759083 http://dx.doi.org/10.1038/ncomms4728 |