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Targeted genomic rearrangements using CRISPR/Cas technology

Genomic rearrangements are frequently observed in cancer cells but have been difficult to generate in a highly specific manner for functional analysis. Here we report the application of CRISPR/Cas technology to successfully generate several types of chromosomal rearrangements implicated as driver ev...

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Detalles Bibliográficos
Autores principales:	Choi, Peter S., Meyerson, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170920/ https://www.ncbi.nlm.nih.gov/pubmed/24759083 http://dx.doi.org/10.1038/ncomms4728

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