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Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies
Modification of antibody class and binding properties typically requires cloning of antibody genes, antibody library construction, phage or yeast display and recombinant antibody expression. Here, we describe an alternative “cloning-free” approach to generate antibodies with altered antigen-binding...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171010/ https://www.ncbi.nlm.nih.gov/pubmed/24874693 http://dx.doi.org/10.4161/mabs.29124 |