Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase

BACKGROUND: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert α-ketoglutarate to 2-hydroxyglutarate, ultimately leading to tumorigenesis. The major source of 2-hydroxyg...

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Detalles Bibliográficos
Autores principales: Izquierdo-Garcia, Jose L., Cai, Larry M., Chaumeil, Myriam M., Eriksson, Pia, Robinson, Aaron E., Pieper, Russell O., Phillips, Joanna J., Ronen, Sabrina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171511/
https://www.ncbi.nlm.nih.gov/pubmed/25243911
http://dx.doi.org/10.1371/journal.pone.0108289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171511/
https://www.ncbi.nlm.nih.gov/pubmed/25243911
http://dx.doi.org/10.1371/journal.pone.0108289

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