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Protease-Dead Separase Is Dominant Negative in the C. elegans Embryo
Separase is a protease that promotes chromosome segregation at anaphase by cleaving cohesin. Several non-proteolytic functions of separase have been identified in other organisms. We created a transgenic C. elegans line that expresses protease-dead separase in embryos to further characterize separas...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171520/ https://www.ncbi.nlm.nih.gov/pubmed/25244427 http://dx.doi.org/10.1371/journal.pone.0108188 |