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Protease-Dead Separase Is Dominant Negative in the C. elegans Embryo

Separase is a protease that promotes chromosome segregation at anaphase by cleaving cohesin. Several non-proteolytic functions of separase have been identified in other organisms. We created a transgenic C. elegans line that expresses protease-dead separase in embryos to further characterize separas...

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Detalles Bibliográficos
Autores principales:	Mitchell, Diana M., Uehlein-Klebanow, Lindsey R., Bembenek, Joshua N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171520/ https://www.ncbi.nlm.nih.gov/pubmed/25244427 http://dx.doi.org/10.1371/journal.pone.0108188

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