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Epigenetic regulation of spinal cord gene expression controls Opioid-Induced Hyperalgesia
BACKGROUND: The long term use of opioids for the treatment of pain leads to a group of maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves within few days after cessation of morphine treatment in mice but is prolonged for weeks if histone deacetylase (HDAC) activi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171542/ https://www.ncbi.nlm.nih.gov/pubmed/25217253 http://dx.doi.org/10.1186/1744-8069-10-59 |