Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

Glutaminase, which converts glutamine to glutamate, is involved in Warburg effect in cancer cells. Two human glutaminase genes have been identified, GLS (GLS1) and GLS2. Two alternative transcripts arise from each glutaminase gene: first, the kidney isoform (KGA) and glutaminase C (GAC) for GLS; and...

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Detalles Bibliográficos
Autores principales: Lee, Yue-Zhi, Yang, Cheng-Wei, Chang, Hsin-Yu, Hsu, Hsing-Yu, Chen, Ih-Shen, Chang, Hsun-Shuo, Lee, Chih-Hao, Lee, Jinq-chyi, Kumar, Chidambaram Ramesh, Qiu, Ya-Qi, Chao, Yu-Sheng, Lee, Shiow-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171615/
https://www.ncbi.nlm.nih.gov/pubmed/25026281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171615/
https://www.ncbi.nlm.nih.gov/pubmed/25026281

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