The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy

Inhibition of Aurora kinase activity by small molecules is being actively investigated as a potential anti-cancer strategy. A successful therapeutic use of Aurora inhibitors relies on a comprehensive understanding of the effects of inactivating Aurora kinases on cell division, a challenging aim give...

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Detalles Bibliográficos
Autores principales: Asteriti, Italia Anna, Cesare, Erica Di, Mattia, Fabiola De, Hilsenstein, Volker, Neumann, Beate, Cundari, Enrico, Lavia, Patrizia, Guarguaglini, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171625/
https://www.ncbi.nlm.nih.gov/pubmed/25153724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171625/
https://www.ncbi.nlm.nih.gov/pubmed/25153724

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