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Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A(2)α via AKT in prostate cancer cells
Aberrant increase in pAKT, due to a gain-of-function mutation of PI3K or loss-of-function mutation or deletion of PTEN, occurs in prostate cancer and is associated with poor patient prognosis. Cytosolic phospholipase A(2)α (cPLA(2)α) is a lipid modifying enzyme by catalyzing the hydrolysis of membra...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171630/ https://www.ncbi.nlm.nih.gov/pubmed/25026288 |