The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

Altered DAB2IP gene expression often detected in prostate cancer (PCa) is due to epigenetic silencing. In this study, we unveil a new mechanism leading to the loss of DAB2IP protein; an oncogenic S-phase kinase-associated protein-2 (Skp2) as E3 ubiquitin ligase plays a key regulator in DAB2IP degrad...

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Detalles Bibliográficos
Autores principales: Tsai, Yuh-Shyan, Lai, Chen-Li, Lai, Chih-Ho, Chang, Kai-Hsiung, Wu, Kaijie, Tseng, Shu-Fen, Fazli, Ladan, Gleave, Martin, Xiao, Guanghua, Gandee, Leah, Sharifi, Nima, Moro, Loredana, Tzai, Tzong-Shin, Hsieh, Jer-Tsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171641/
https://www.ncbi.nlm.nih.gov/pubmed/25115390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171641/
https://www.ncbi.nlm.nih.gov/pubmed/25115390

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