BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency

Irs2-deficient mice develop type 2–like diabetes due to a reduction in β-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in response to insulin resistance. In order to define the molecular mechanisms, we knocked down Irs2 gene expression in mouse MIN6 insulinoma cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Decheng, Sun, Juan, Mao, Liqun, Ye, Honggang, Polonsky, Kenneth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171655/
https://www.ncbi.nlm.nih.gov/pubmed/24760140
http://dx.doi.org/10.2337/db13-1814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171655/
https://www.ncbi.nlm.nih.gov/pubmed/24760140
http://dx.doi.org/10.2337/db13-1814

Ejemplares similares