ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions

Autoantibodies to the islet-specific Zn transporter ZnT8 (Slc30a8), as well as CD4 T cells, have been identified in patients with type 1 diabetes. Here we examined for CD4 T-cell reactivity to ZnT8 epitopes in the NOD mouse. Immunization with a cytoplasmic domain of the protein or with peptides pred...

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Detalles Bibliográficos
Autores principales: Nayak, Deepak K., Calderon, Boris, Vomund, Anthony N., Unanue, Emil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171664/
https://www.ncbi.nlm.nih.gov/pubmed/24812429
http://dx.doi.org/10.2337/db13-1882