The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition

Metastatic carcinoma cells exhibit at least two different phenotypes of motility and invasion - amoeboid and mesenchymal. This plasticity poses a major clinical challenge for treating metastasis, while its underlying mechanisms remain enigmatic. Transitions between these phenotypes are mediated by t...

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Detalles Bibliográficos
Autores principales: Huang, Bin, Lu, Mingyang, Jolly, Mohit Kumar, Tsarfaty, Ilan, Onuchic, José, Ben-Jacob, Eshel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171704/
https://www.ncbi.nlm.nih.gov/pubmed/25245029
http://dx.doi.org/10.1038/srep06449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171704/
https://www.ncbi.nlm.nih.gov/pubmed/25245029
http://dx.doi.org/10.1038/srep06449

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