Pharmacogenetic Selection of Volunteers Increases Stringency of Bioequivalence Studies; The Case of Clopidogrel

Clinical response to clopidogrel varies widely due to under-dosing, drug interactions and intrinsic interindividual differences resulting from genetic polymorphisms. Cytochrome P450-2C19 is the principal enzyme involved in the activation of the prodrug and loss-of-function alleles have been describe...

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Detalles Bibliográficos
Autores principales: Garcés-Eisele, J., Ruiz-Argüelles, A., Estrada-Marín, Larisa, Reyes-Núñez, Virginia, Vázquez-Pérez, R., Guzmán-García, Olga, Coutiño-Medina, R., Acosta-Sandria, Leticia, Cedillo-Carvallo, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171864/
https://www.ncbi.nlm.nih.gov/pubmed/25284925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171864/
https://www.ncbi.nlm.nih.gov/pubmed/25284925

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