Synthetic Lethality Reveals Mechanisms of Mycobacterium tuberculosis Resistance to β-Lactams

Most β-lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe’s innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has prompted interest to repurpose this class of drugs. To identify the genetic determinants of...

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Detalles Bibliográficos
Autores principales: Lun, Shichun, Miranda, David, Kubler, Andre, Guo, Haidan, Maiga, Mariama C., Winglee, Kathryn, Pelly, Shaaretha, Bishai, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172077/
https://www.ncbi.nlm.nih.gov/pubmed/25227469
http://dx.doi.org/10.1128/mBio.01767-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172077/
https://www.ncbi.nlm.nih.gov/pubmed/25227469
http://dx.doi.org/10.1128/mBio.01767-14

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