Small Molecule Inhibition of the Na(+)/H(+) Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction

[Image: see text] We have identified a series of small molecules that bind to the canonical peptide binding groove of the PDZ1 domain of NHERF1 and effectively compete with the association of the C-terminus of the parathyroid hormone 1 receptor (PTH1R). Employing nuclear magnetic resonance and molec...

Descripción completa

Detalles Bibliográficos
Autores principales: Fitzpatrick, Jeremy M., Pellegrini, Maria, Cushing, Patrick R., Mierke, Dale F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172209/
https://www.ncbi.nlm.nih.gov/pubmed/25171053
http://dx.doi.org/10.1021/bi500368k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172209/
https://www.ncbi.nlm.nih.gov/pubmed/25171053
http://dx.doi.org/10.1021/bi500368k

Ejemplares similares