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Small Molecule Inhibition of the Na(+)/H(+) Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction
[Image: see text] We have identified a series of small molecules that bind to the canonical peptide binding groove of the PDZ1 domain of NHERF1 and effectively compete with the association of the C-terminus of the parathyroid hormone 1 receptor (PTH1R). Employing nuclear magnetic resonance and molec...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172209/ https://www.ncbi.nlm.nih.gov/pubmed/25171053 http://dx.doi.org/10.1021/bi500368k |