Enhanced Immunogenicity of HIV-1 Envelope gp140 Proteins Fused to APRIL

Current HIV-1 vaccines based on the HIV-1 envelope glycoprotein spike (Env), the only relevant target for broadly neutralizing antibodies, are unable to induce protective immunity. Env immunogenicity can be enhanced by fusion to costimulatory molecules involved in B cell activation, such as APRIL an...

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Detalles Bibliográficos
Autores principales: Isik, Gözde, Sliepen, Kwinten, van Montfort, Thijs, Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172553/
https://www.ncbi.nlm.nih.gov/pubmed/25247707
http://dx.doi.org/10.1371/journal.pone.0107683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172553/
https://www.ncbi.nlm.nih.gov/pubmed/25247707
http://dx.doi.org/10.1371/journal.pone.0107683

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