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Enhanced Immunogenicity of HIV-1 Envelope gp140 Proteins Fused to APRIL
Current HIV-1 vaccines based on the HIV-1 envelope glycoprotein spike (Env), the only relevant target for broadly neutralizing antibodies, are unable to induce protective immunity. Env immunogenicity can be enhanced by fusion to costimulatory molecules involved in B cell activation, such as APRIL an...
Autores principales: | Isik, Gözde, Sliepen, Kwinten, van Montfort, Thijs, Sanders, Rogier W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172553/ https://www.ncbi.nlm.nih.gov/pubmed/25247707 http://dx.doi.org/10.1371/journal.pone.0107683 |
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