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Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteolytic Activities
Mammalian HtrA (high temperature requirement factor A) proteases, comprising 4 multi-domain members HtrA1-4, play important roles in a number of normal cellular processes as well as pathological conditions such as cancer, arthritis, neurodegenerative diseases and pregnancy disorders. However, how Ht...
Autores principales: | Singh, Harmeet, Nero, Tracy L., Wang, Yao, Parker, Michael W., Nie, Guiying |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172569/ https://www.ncbi.nlm.nih.gov/pubmed/25248123 http://dx.doi.org/10.1371/journal.pone.0108235 |
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