Cargando…

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

The nematode worm Caenorhabditis elegans provides a powerful system for elucidating how genetic, metabolic, nutritional, and environmental factors influence aging. The mechanistic target of rapamycin (mTOR) kinase is important in growth, disease, and aging and is present in the mTORC1 and mTORC2 com...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mizunuma, Masaki, Neumann-Haefelin, Elke, Moroz, Natalie, Li, Yujie, Blackwell, T Keith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172656/ https://www.ncbi.nlm.nih.gov/pubmed/25040785 http://dx.doi.org/10.1111/acel.12248

Ejemplares similares

CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans
por: Li, Yujie, et al.
Publicado: (2018)

mTORC2 takes the longevity stAGE
por: Lamming, Dudley W.
Publicado: (2014)

Hypothalamic mTORC2 is essential for metabolic health and longevity
por: Chellappa, Karthikeyani, et al.
Publicado: (2019)

mTORC1 is also involved in longevity between species
por: Barja, Gustavo, et al.
Publicado: (2021)

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
por: Statzer, Cyril, et al.
Publicado: (2022)

Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans
por: Gatsi, Roxani, et al.
Publicado: (2014)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma
por: Ganner, Athina, et al.
Publicado: (2021)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages
por: Huynh, Linda, et al.
Publicado: (2016)

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma
por: Akgül, Seçkin, et al.
Publicado: (2018)

The AGC kinase serum- and glucocorticoid-regulated kinase 1 (SGK1) regulates T(H)1 and T(H)2 differentiation downstream of mTORC2
por: Heikamp, Emily B., et al.
Publicado: (2014)

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
por: Castel, Pau, et al.
Publicado: (2016)

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
por: Bago, Ruzica, et al.
Publicado: (2016)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Something to mTORC About in NASH
por: Finck, Brian N.
Publicado: (2022)

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity
por: Huang, Wenming, et al.
Publicado: (2022)

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans
por: Smith, Hannah J., et al.
Publicado: (2023)

Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis
por: Tasneen, Rokeya, et al.
Publicado: (2021)

Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt
por: Yu, Zanlin, et al.
Publicado: (2022)

Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1
por: Brincks, Erik L., et al.
Publicado: (2020)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uapan47nsalgidh9fca65vmd2i