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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity

BACKGROUND: Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport proteins are particularly involve...

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Detalles Bibliográficos
Autores principales:	Rijpma, Sanna R, van den Heuvel, Jeroen JMW, van der Velden, Maarten, Sauerwein, Robert W, Russel, Frans GM, Koenderink, Jan B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172838/ https://www.ncbi.nlm.nih.gov/pubmed/25218605 http://dx.doi.org/10.1186/1475-2875-13-359

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