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A prominent and conserved role for YY1 in Xist transcriptional activation

Accumulation of the non-coding RNA Xist on one X chromosome in female cells is a hallmark of X-chromosome inactivation in eutherians. Here, we uncovered an essential function for the ubiquitous autosomal transcription factor Yin-Yang 1 (YY1) in the transcriptional activation of Xist in both human an...

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Detalles Bibliográficos
Autores principales: Makhlouf, Mélanie, Ouimette, Jean-François, Oldfield, Andrew, Navarro, Pablo, Neuillet, Damien, Rougeulle, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172967/
https://www.ncbi.nlm.nih.gov/pubmed/25209548
http://dx.doi.org/10.1038/ncomms5878