ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes

ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis. How ZNF750 accomplishes these dual gene regulatory impacts is unknown. Here, we characterized ZNF750 as a transcripti...

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Detalles Bibliográficos
Autores principales: Boxer, Lisa D., Barajas, Brook, Tao, Shiying, Zhang, Jiajing, Khavari, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173152/
https://www.ncbi.nlm.nih.gov/pubmed/25228645
http://dx.doi.org/10.1101/gad.246579.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173152/
https://www.ncbi.nlm.nih.gov/pubmed/25228645
http://dx.doi.org/10.1101/gad.246579.114

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