Nascent RNA interaction keeps PRC2 activity poised and in check

Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of chromatin domains repressive to transcription through catalysis of methylation of histone H3 at Lys27 (H3K27me2/3). However, through its EZH2 subunit, PRC2 also binds to nascent transcripts from active genes that are...

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Detalles Bibliográficos
Autores principales: Kaneko, Syuzo, Son, Jinsook, Bonasio, Roberto, Shen, Steven S., Reinberg, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173153/
https://www.ncbi.nlm.nih.gov/pubmed/25170018
http://dx.doi.org/10.1101/gad.247940.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173153/
https://www.ncbi.nlm.nih.gov/pubmed/25170018
http://dx.doi.org/10.1101/gad.247940.114

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