Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

The mammalian circadian clock is based on a transcription–translation feedback loop (TTFL) in which CLOCK and BMAL1 proteins act as transcriptional activators of Cryptochrome and Period genes, which encode proteins that repress CLOCK–BMAL1 with a periodicity of ∼24 h. In this model, the mechanistic...

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Detalles Bibliográficos
Autores principales: Ye, Rui, Selby, Cristopher P., Chiou, Yi-Ying, Ozkan-Dagliyan, Irem, Gaddameedhi, Shobhan, Sancar, Aziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173159/
https://www.ncbi.nlm.nih.gov/pubmed/25228643
http://dx.doi.org/10.1101/gad.249417.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173159/
https://www.ncbi.nlm.nih.gov/pubmed/25228643
http://dx.doi.org/10.1101/gad.249417.114

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