Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor

B-cell activating factor (BAFF) is a B-cell survival factor with a key role in B-cell homeostasis and tolerance. Dysregulated BAFF expression may contribute to autoimmune diseases or B-cell malignancies via effects on abnormal B-lymphocyte activation, proliferation, survival, and immunoglobulin secr...

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Detalles Bibliográficos
Autores principales: Manetta, Joseph, Bina, Holly, Ryan, Paul, Fox, Niles, Witcher, Derrick R, Kikly, Kristine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173659/
https://www.ncbi.nlm.nih.gov/pubmed/25258549
http://dx.doi.org/10.2147/JIR.S67751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173659/
https://www.ncbi.nlm.nih.gov/pubmed/25258549
http://dx.doi.org/10.2147/JIR.S67751

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