Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

Protein misfolding is implicated in numerous lethal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). There are no therapies that reverse these protein-misfolding events. We aim to apply Hsp104, a hexameric AAA+ protein from yeast, to target misfo...

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Detalles Bibliográficos
Autores principales: Jackrel, Meredith E., Shorter, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174528/
https://www.ncbi.nlm.nih.gov/pubmed/25062688
http://dx.doi.org/10.1242/dmm.016113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174528/
https://www.ncbi.nlm.nih.gov/pubmed/25062688
http://dx.doi.org/10.1242/dmm.016113

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