Cargando…

Validating Antibodies to the Cannabinoid CB2 Receptor: Antibody Sensitivity Is Not Evidence of Antibody Specificity

Antibody-based methods for the detection and quantification of membrane integral proteins, in particular, the G protein-coupled receptors (GPCRs), have been plagued with issues of primary antibody specificity. In this report, we investigate one of the most commonly utilized commercial antibodies for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marchalant, Yannick, Brownjohn, Philip W., Bonnet, Amandine, Kleffmann, Torsten, Ashton, John C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174627/ https://www.ncbi.nlm.nih.gov/pubmed/24670796 http://dx.doi.org/10.1369/0022155414530995

Ejemplares similares

Cannabinoid CB(1) and CB(2) Receptor Signaling and Bias
por: Ibsen, Mikkel Søes, et al.
Publicado: (2017)

Cannabigerol Action at Cannabinoid CB(1) and CB(2) Receptors and at CB(1)–CB(2) Heteroreceptor Complexes
por: Navarro, Gemma, et al.
Publicado: (2018)

Cannabinoid CB1 receptors regulate salivation
por: Andreis, Kelsey, et al.
Publicado: (2022)

Voltage dependence of the cannabinoid CB1 receptor
por: Goldberger, Esty, et al.
Publicado: (2022)

Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?
por: Marchalant, Yannick, et al.
Publicado: (2012)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Expression and Function of Cannabinoid Receptors CB1 and CB2 and Their Cognate Cannabinoid Ligands in Murine Embryonic Stem Cells
por: Jiang, Shuxian, et al.
Publicado: (2007)

Solid-phase synthesis of imprinted nanoparticles as artificial antibodies against the C-terminus of the cannabinoid CB1 receptor: exploring a viable alternative for bioanalysis
por: Gómez-Caballero, Alberto, et al.
Publicado: (2021)

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys
por: Bouskila, Joseph, et al.
Publicado: (2016)

Cannabinoid Receptor CB(2) Modulates Axon Guidance
por: Duff, Gabriel, et al.
Publicado: (2013)

CB1 Cannabinoid Receptor Signaling and Biased Signaling
por: Leo, Luciana M., et al.
Publicado: (2021)

Editorial: Therapeutic potential of the cannabinoid CB2 receptor
por: Smoum, Reem, et al.
Publicado: (2022)

Microglial Cannabinoid CB(2) Receptors in Pain Modulation
por: Xu, Kangtai, et al.
Publicado: (2023)

Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
por: Echeazarra, Leyre, et al.
Publicado: (2021)

Circuit Specific Functions of Cannabinoid CB1 Receptor in the Balance of Investigatory Drive and Exploration
por: Häring, Martin, et al.
Publicado: (2011)

Effects of pro‐inflammatory cytokines on cannabinoid CB (1) and CB (2) receptors in immune cells
por: Jean‐Gilles, L., et al.
Publicado: (2015)

Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms
por: Soderstrom, Ken, et al.
Publicado: (2017)

Functional characterization of the novel cannabinoid receptor GPR55 and its modulation by CB(1 )and CB(2 )receptors
por: Balenga, Nariman, et al.
Publicado: (2008)

Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity
por: Franks, Lirit N., et al.
Publicado: (2016)

Loss of Cannabinoid Receptor CB1 Induces Preterm Birth
por: Wang, Haibin, et al.
Publicado: (2008)

Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS
por: Onaivi, E.S
Publicado: (2011)

Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis
por: Björklund, Emmelie, et al.
Publicado: (2011)

Cannabinoid CB(1) Receptors Mediate the Gastroprotective Effect of Neurotensin
por: Hassanzadeh, Parichehr, et al.
Publicado: (2012)

Cardiorespiratory Anomalies in Mice Lacking CB(1) Cannabinoid Receptors
por: Silvani, Alessandro, et al.
Publicado: (2014)

THC Regulates Tearing via Cannabinoid CB1 Receptors
por: Thayer, Amanda, et al.
Publicado: (2020)

Chain Substituted Cannabilactones with Selectivity for the CB2 Cannabinoid Receptor
por: Alapafuja, Shakiru O., et al.
Publicado: (2019)

Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor
por: Morales, Paula, et al.
Publicado: (2020)

Cholesterol as a modulator of cannabinoid receptor CB(2) signaling
por: Yeliseev, Alexei, et al.
Publicado: (2021)

Structural basis of selective cannabinoid CB(2) receptor activation
por: Li, Xiaoting, et al.
Publicado: (2023)

PM288. Preclinical Evaluation of Neutral Cannabinoid CB1 Receptor Antagonists and Cannabinoid CB1 Receptor Negative Allosteric Modulators for Treating Drug Addiction
por: Gardner, Eliot L., et al.
Publicado: (2016)

Evidence for a novel functional role of cannabinoid CB(2) receptors in the thalamus of neuropathic rats
por: Jhaveri, M D, et al.
Publicado: (2008)

Mice expressing a “hyper-sensitive” form of the CB(1) cannabinoid receptor (CB(1)) show modestly enhanced alcohol preference and consumption
por: Marcus, David J., et al.
Publicado: (2017)

An Update on Non-CB(1), Non-CB(2) Cannabinoid Related G-Protein-Coupled Receptors
por: Morales, Paula, et al.
Publicado: (2017)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB(1)/CB(2) Receptor Interaction
por: Asproni, Battistina, et al.
Publicado: (2021)

Immunolocalization of cannabinoid receptor type 1 and CB2 cannabinoid receptors, and transient receptor potential vanilloid channels in pterygium
por: Assimakopoulou, Martha, et al.
Publicado: (2017)

Cannabinoid CB(2) Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
por: Burston, James J., et al.
Publicado: (2013)

Cannabinoid(1) (CB-1) receptor antagonists: a molecular approach to treating acute cannabinoid overdose
por: Skolnick, Phil, et al.
Publicado: (2019)

Stimulation of cannabinoid receptor 2 (CB(2)) suppresses microglial activation
por: Ehrhart, Jared, et al.
Publicado: (2005)

Brain Cannabinoid CB(2) Receptors Modulate Cocaine’s Actions in Mice
por: Xi, Zheng-Xiong, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ptrck0tntdvnnoa8ph0jmom9hi