Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system

BACKGROUND: Synthetic double-stranded RNA poly(I:C) is a useful immune adjuvant and exhibits direct antitumor effects against several types of cancers. In this study, we elucidated the mechanisms underlying the effects induced in poly(I:C)-transfected human renal cell carcinoma (RCC) cells. RESULTS:...

Descripción completa

Detalles Bibliográficos
Autores principales: Harashima, Nanae, Minami, Takafumi, Uemura, Hirotsugu, Harada, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174632/
https://www.ncbi.nlm.nih.gov/pubmed/25227113
http://dx.doi.org/10.1186/1476-4598-13-217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174632/
https://www.ncbi.nlm.nih.gov/pubmed/25227113
http://dx.doi.org/10.1186/1476-4598-13-217

Ejemplares similares