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Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system

BACKGROUND: Synthetic double-stranded RNA poly(I:C) is a useful immune adjuvant and exhibits direct antitumor effects against several types of cancers. In this study, we elucidated the mechanisms underlying the effects induced in poly(I:C)-transfected human renal cell carcinoma (RCC) cells. RESULTS:...

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Detalles Bibliográficos
Autores principales:	Harashima, Nanae, Minami, Takafumi, Uemura, Hirotsugu, Harada, Mamoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174632/ https://www.ncbi.nlm.nih.gov/pubmed/25227113 http://dx.doi.org/10.1186/1476-4598-13-217

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