A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium

The full-length isoform of matrixmetalloproteinase-2 (FL-MMP-2) plays a role in turnover of the cardiac extracellular matrix. FL-MMP-2 is also present intracellularly in association with sarcomeres and, in the setting of oxidative stress, cleaves myofilament proteins with resultant impaired contract...

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Detalles Bibliográficos
Autores principales: Lovett, David H., Chu, Charles, Wang, Guanying, Ratcliffe, Mark B., Baker, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174733/
https://www.ncbi.nlm.nih.gov/pubmed/25309453
http://dx.doi.org/10.3389/fphys.2014.00363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174733/
https://www.ncbi.nlm.nih.gov/pubmed/25309453
http://dx.doi.org/10.3389/fphys.2014.00363

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