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A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium
The full-length isoform of matrixmetalloproteinase-2 (FL-MMP-2) plays a role in turnover of the cardiac extracellular matrix. FL-MMP-2 is also present intracellularly in association with sarcomeres and, in the setting of oxidative stress, cleaves myofilament proteins with resultant impaired contract...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174733/ https://www.ncbi.nlm.nih.gov/pubmed/25309453 http://dx.doi.org/10.3389/fphys.2014.00363 |