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Interactions between Amyloid-β and Tau Fragments Promote Aberrant Aggregates: Implications for Amyloid Toxicity

[Image: see text] We have investigated at the oligomeric level interactions between Aβ(25–35) and Tau(273–284), two important fragments of the amyloid-β and Tau proteins, implicated in Alzheimer’s disease. We are able to directly observe the coaggregation of these two peptides by probing the conform...

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Detalles Bibliográficos
Autores principales: Do, Thanh D., Economou, Nicholas J., Chamas, Ali, Buratto, Steven K., Shea, Joan-Emma, Bowers, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174992/
https://www.ncbi.nlm.nih.gov/pubmed/25153942
http://dx.doi.org/10.1021/jp506258g