Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)

[Image: see text] The recent discovery of allosteric modulators of the CB1 receptor including PSNCBAM-1 (4) has generated significant interest in CB1 receptor allosteric modulation. Here in the first SAR study on 4, we have designed and synthesized a series of analogs focusing on modifications at tw...

Descripción completa

Detalles Bibliográficos
Autores principales: German, Nadezhda, Decker, Ann M., Gilmour, Brian P., Gay, Elaine A., Wiley, Jenny L., Thomas, Brian F., Zhang, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175001/
https://www.ncbi.nlm.nih.gov/pubmed/25162172
http://dx.doi.org/10.1021/jm501042u

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175001/
https://www.ncbi.nlm.nih.gov/pubmed/25162172
http://dx.doi.org/10.1021/jm501042u

Ejemplares similares