Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition

BACKGROUND: Lysine Specific Demethylase (LSD1 or KDM1A) in complex with its co-repressor protein CoREST catalyzes the demethylation of the H3 histone N-terminal tail and is currently one of the most promising epigenetic targets for drug discovery against cancer and neurodegenerative diseases. Models...

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Detalles Bibliográficos
Autores principales: Vellore, Nadeem A, Baron, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175114/
https://www.ncbi.nlm.nih.gov/pubmed/24274367
http://dx.doi.org/10.1186/2046-1682-6-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175114/
https://www.ncbi.nlm.nih.gov/pubmed/24274367
http://dx.doi.org/10.1186/2046-1682-6-15

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