Reconstitution of a Minimal Ribosome-Associated Ubiquitination Pathway with Purified Factors

Ribosomes stalled on aberrant mRNAs engage quality control mechanisms that degrade the partially translated nascent polypeptide. Ubiquitination of the nascent protein is mediated by the E3 ligase Listerin via a mechanism involving ribosome subunit dissociation. Here, we reconstitute ribosome-associa...

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Detalles Bibliográficos
Autores principales: Shao, Sichen, Hegde, Ramanujan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175178/
https://www.ncbi.nlm.nih.gov/pubmed/25132172
http://dx.doi.org/10.1016/j.molcel.2014.07.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175178/
https://www.ncbi.nlm.nih.gov/pubmed/25132172
http://dx.doi.org/10.1016/j.molcel.2014.07.006

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