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Reconstitution of a Minimal Ribosome-Associated Ubiquitination Pathway with Purified Factors
Ribosomes stalled on aberrant mRNAs engage quality control mechanisms that degrade the partially translated nascent polypeptide. Ubiquitination of the nascent protein is mediated by the E3 ligase Listerin via a mechanism involving ribosome subunit dissociation. Here, we reconstitute ribosome-associa...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175178/ https://www.ncbi.nlm.nih.gov/pubmed/25132172 http://dx.doi.org/10.1016/j.molcel.2014.07.006 |