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PARP inhibitors: current status and implications for anticancer therapeutics

Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PAR...

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Detalles Bibliográficos
Autores principales: Usmani, Hadi, Hussain, Syed Ather, Sheikh, Asfandyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175919/
https://www.ncbi.nlm.nih.gov/pubmed/24289880
http://dx.doi.org/10.1186/1750-9378-8-46