PARP inhibitors: current status and implications for anticancer therapeutics

Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PAR...

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Detalles Bibliográficos
Autores principales: Usmani, Hadi, Hussain, Syed Ather, Sheikh, Asfandyar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175919/
https://www.ncbi.nlm.nih.gov/pubmed/24289880
http://dx.doi.org/10.1186/1750-9378-8-46
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author Usmani, Hadi
Hussain, Syed Ather
Sheikh, Asfandyar
author_facet Usmani, Hadi
Hussain, Syed Ather
Sheikh, Asfandyar
author_sort Usmani, Hadi
collection PubMed
description Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PARP 1 and PARP 2. These drugs seem to target tumor cells in a moment of vulnerability when they are undergoing DNA repair. In the past few years this class of anti-cancer drug has been discovered to show a promising niche in the clinic.
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spelling pubmed-41759192014-09-27 PARP inhibitors: current status and implications for anticancer therapeutics Usmani, Hadi Hussain, Syed Ather Sheikh, Asfandyar Infect Agent Cancer Letter to the Editor Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PARP 1 and PARP 2. These drugs seem to target tumor cells in a moment of vulnerability when they are undergoing DNA repair. In the past few years this class of anti-cancer drug has been discovered to show a promising niche in the clinic. BioMed Central 2013-12-02 /pmc/articles/PMC4175919/ /pubmed/24289880 http://dx.doi.org/10.1186/1750-9378-8-46 Text en Copyright © 2013 Usmani et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Usmani, Hadi
Hussain, Syed Ather
Sheikh, Asfandyar
PARP inhibitors: current status and implications for anticancer therapeutics
title PARP inhibitors: current status and implications for anticancer therapeutics
title_full PARP inhibitors: current status and implications for anticancer therapeutics
title_fullStr PARP inhibitors: current status and implications for anticancer therapeutics
title_full_unstemmed PARP inhibitors: current status and implications for anticancer therapeutics
title_short PARP inhibitors: current status and implications for anticancer therapeutics
title_sort parp inhibitors: current status and implications for anticancer therapeutics
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175919/
https://www.ncbi.nlm.nih.gov/pubmed/24289880
http://dx.doi.org/10.1186/1750-9378-8-46
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