Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Mutations in Leucine-Rich Repeat Kinase-2 (LRRK2) result in familial Parkinson's disease and the G2019S mutation alone accounts for up to 30% in some ethnicities. Despite this, the function of LRRK2 is largely undetermined although evidence suggests roles in phosphorylation, protein interaction...

Descripción completa

Detalles Bibliográficos
Autores principales: Beccano-Kelly, Dayne A., Kuhlmann, Naila, Tatarnikov, Igor, Volta, Mattia, Munsie, Lise N., Chou, Patrick, Cao, Li-Ping, Han, Heather, Tapia, Lucia, Farrer, Matthew J., Milnerwood, Austen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176085/
https://www.ncbi.nlm.nih.gov/pubmed/25309331
http://dx.doi.org/10.3389/fncel.2014.00301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176085/
https://www.ncbi.nlm.nih.gov/pubmed/25309331
http://dx.doi.org/10.3389/fncel.2014.00301

Ejemplares similares